Cardiac stress test is normal in pre-motor Parkinson's disease.
Identifieur interne : 000649 ( Main/Exploration ); précédent : 000648; suivant : 000650Cardiac stress test is normal in pre-motor Parkinson's disease.
Auteurs : Gilad Yahalom [Israël] ; Elad Maor ; Sharon Hassin-Baer ; Shlomo Segev ; Yechezkel Sidi ; Shaye KivitySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Heart Diseases.
- physiology : Blood Pressure, Heart Rate.
- Aged, Case-Control Studies, Cohort Studies, Ergometry, Exercise Test, Female, Humans, Male, Middle Aged.
Abstract
Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow-up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years, P < 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (P < 0.001) and lower heart rate reserve than healthy controls (P < 0.001); however, compared with age- and sex-matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD.
DOI: 10.1002/mds.25943
PubMed: 24954917
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000469
- to stream PubMed, to step Curation: 000469
- to stream PubMed, to step Checkpoint: 000666
- to stream Ncbi, to step Merge: 004034
- to stream Ncbi, to step Curation: 004034
- to stream Ncbi, to step Checkpoint: 004034
- to stream Main, to step Merge: 000649
- to stream Main, to step Curation: 000649
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac stress test is normal in pre-motor Parkinson's disease.</title><author><name sortKey="Yahalom, Gilad" sort="Yahalom, Gilad" uniqKey="Yahalom G" first="Gilad" last="Yahalom">Gilad Yahalom</name><affiliation wicri:level="1"><nlm:affiliation>The Parkinson Disease and Movement Disorders Clinic, Department of Neurology and Sagol Neuroscience Center; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Parkinson Disease and Movement Disorders Clinic, Department of Neurology and Sagol Neuroscience Center; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea><wicri:noRegion>Tel-Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Maor, Elad" sort="Maor, Elad" uniqKey="Maor E" first="Elad" last="Maor">Elad Maor</name></author><author><name sortKey="Hassin Baer, Sharon" sort="Hassin Baer, Sharon" uniqKey="Hassin Baer S" first="Sharon" last="Hassin-Baer">Sharon Hassin-Baer</name></author><author><name sortKey="Segev, Shlomo" sort="Segev, Shlomo" uniqKey="Segev S" first="Shlomo" last="Segev">Shlomo Segev</name></author><author><name sortKey="Sidi, Yechezkel" sort="Sidi, Yechezkel" uniqKey="Sidi Y" first="Yechezkel" last="Sidi">Yechezkel Sidi</name></author><author><name sortKey="Kivity, Shaye" sort="Kivity, Shaye" uniqKey="Kivity S" first="Shaye" last="Kivity">Shaye Kivity</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24954917</idno><idno type="pmid">24954917</idno><idno type="doi">10.1002/mds.25943</idno><idno type="wicri:Area/PubMed/Corpus">000469</idno><idno type="wicri:Area/PubMed/Curation">000469</idno><idno type="wicri:Area/PubMed/Checkpoint">000666</idno><idno type="wicri:Area/Ncbi/Merge">004034</idno><idno type="wicri:Area/Ncbi/Curation">004034</idno><idno type="wicri:Area/Ncbi/Checkpoint">004034</idno><idno type="wicri:Area/Main/Merge">000649</idno><idno type="wicri:Area/Main/Curation">000649</idno><idno type="wicri:Area/Main/Exploration">000649</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cardiac stress test is normal in pre-motor Parkinson's disease.</title><author><name sortKey="Yahalom, Gilad" sort="Yahalom, Gilad" uniqKey="Yahalom G" first="Gilad" last="Yahalom">Gilad Yahalom</name><affiliation wicri:level="1"><nlm:affiliation>The Parkinson Disease and Movement Disorders Clinic, Department of Neurology and Sagol Neuroscience Center; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Parkinson Disease and Movement Disorders Clinic, Department of Neurology and Sagol Neuroscience Center; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea><wicri:noRegion>Tel-Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Maor, Elad" sort="Maor, Elad" uniqKey="Maor E" first="Elad" last="Maor">Elad Maor</name></author><author><name sortKey="Hassin Baer, Sharon" sort="Hassin Baer, Sharon" uniqKey="Hassin Baer S" first="Sharon" last="Hassin-Baer">Sharon Hassin-Baer</name></author><author><name sortKey="Segev, Shlomo" sort="Segev, Shlomo" uniqKey="Segev S" first="Shlomo" last="Segev">Shlomo Segev</name></author><author><name sortKey="Sidi, Yechezkel" sort="Sidi, Yechezkel" uniqKey="Sidi Y" first="Yechezkel" last="Sidi">Yechezkel Sidi</name></author><author><name sortKey="Kivity, Shaye" sort="Kivity, Shaye" uniqKey="Kivity S" first="Shaye" last="Kivity">Shaye Kivity</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood Pressure (physiology)</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Ergometry</term><term>Exercise Test</term><term>Female</term><term>Heart Diseases (etiology)</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Heart Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term><term>Heart Rate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Ergometry</term><term>Exercise Test</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow-up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years, P < 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (P < 0.001) and lower heart rate reserve than healthy controls (P < 0.001); however, compared with age- and sex-matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD.</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><noCountry><name sortKey="Hassin Baer, Sharon" sort="Hassin Baer, Sharon" uniqKey="Hassin Baer S" first="Sharon" last="Hassin-Baer">Sharon Hassin-Baer</name><name sortKey="Kivity, Shaye" sort="Kivity, Shaye" uniqKey="Kivity S" first="Shaye" last="Kivity">Shaye Kivity</name><name sortKey="Maor, Elad" sort="Maor, Elad" uniqKey="Maor E" first="Elad" last="Maor">Elad Maor</name><name sortKey="Segev, Shlomo" sort="Segev, Shlomo" uniqKey="Segev S" first="Shlomo" last="Segev">Shlomo Segev</name><name sortKey="Sidi, Yechezkel" sort="Sidi, Yechezkel" uniqKey="Sidi Y" first="Yechezkel" last="Sidi">Yechezkel Sidi</name></noCountry><country name="Israël"><noRegion><name sortKey="Yahalom, Gilad" sort="Yahalom, Gilad" uniqKey="Yahalom G" first="Gilad" last="Yahalom">Gilad Yahalom</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000649 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000649 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24954917
|texte= Cardiac stress test is normal in pre-motor Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24954917" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |